American Women and Flight since 1940

Women run wind tunnel experiments, direct air traffic, and fabricate airplanes. American women have been involved with flight from the beginning, but until 1940, most people believed women could not fly, that Amelia Earhart was an exception to the rule. World War II changed everything. “It is on the record that women can fly as well as men,” stated General Henry H. Arnold, commanding general of the Army Air Forces. The question became “Should women fly?” Deborah G. Douglas tells the story of this ongoing debate and its impact on American history. From Jackie Cochran, whose perseverance led to the formation of the Women’s Army Service Pilots (WASP) during World War II to the recent achievements of Jeannie Flynn, the Air Force’s first woman fighter pilot and Eileen Collins, NASA’s first woman shuttle commander, Douglas introduces a host of determined women who overcame prejudice and became military fliers, airline pilots, and air and space engineers. Not forgotten are stories of flight attendants, air traffic controllers, and mechanics. American Women and Flight since 1940 is a revised and expanded edition of a Smithsonian National Air and Space Museum reference work. Long considered the single best reference work in the field, this new edition contains extensive new illustrations and a comprehensive bibliography. I have nothing but admiration for Douglas’s expanded account of the many contribution women have made to the history of flight. -- Ann Carl, author of A Wasp Among Eagles A wonderful service to all women in aviation. From the Air Transport Auxiliary of the 1940s—we 24 gals that Jackie Cochrane took to England to ferry aircraft—to the present, this book will be an essential tool for students and researchers. -- Ann Wood-Kelly, original member of the ATA, later Staff Vice President of Pan Am An accomplished historian, Debbie Douglas has written the authoritative account of contemporary American women’s contributions to civil and military aviation. Based on solid scholarship, this even-handed book documents not only women’s numerous aerial feats, but what transpired on the ground for them to be able to achieve in the air. -- Capt. Rosemary Bryant Mariner, United States Navy (Ret.), former tactical jet pilot An excellent survey of the progress and accomplishments of women in all aspects of aviation in the second half of the 20th century. Douglas reveals the hard-fought struggle to attain real equality in the cockpit, as part of the larger societal struggle, and her first-rate bibliography includes non-aviation gender titles and studies. The book is an important motivational and educational resource for young women. -- Dorothy Cochrane, Curator, Aeronautics Division, National Air and Space Museum The numbers of women pilots sharing the skies with men have advanced at turtle-speed. However, Deborah Douglas offers evidence that women of talent and persistence are making dramatic inroad into all fields of aviation. Her powerful story offers assurance to every young girl that only the imagination, not the sky, is the limit. -- Gene Nora Jessen, author of The Powder Puff Derby of 1929 An interesting and compelling read about awe-inspiring women who pursued their passion against imposing odds and often with extreme sacrifice. -- H-Minerva Reading like a novel, but too unbelievable to be one, Debbie Douglas\u27 work is a powerful statement of how women have changed the world of flight. -- Roger Launius, Chair, Division of Space History, Smithsonian Institution This book . . . is not just about obstacles and barriers; it is just as much about the vital roles women have played in aviation, and it has implications that are broader than just women\u27s history. -- Technology and Culture Provides a thorough analysis of the barriers women had to overcome in aviation, even in roles more socially acceptable than pilot, astronaut, or air-traffic controller. -- Wellesley Magazinehttps://uknowledge.uky.edu/upk_history_of_science_technology_and_medicine/1000/thumbnail.jp

Covered self-expandable metal stents for pancreatic duct stricture: a systematic review and meta-analysis

Background and study aims Placement of a covered (C)-self-expandable metal stent (SEMS) has been recently investigated as an alternative endoscopic treatment for main pancreatic duct stricture (MPDS) in chronic pancreatitis. Our aim was to carry out a systematic review and meta-analysis of studies quantifying efficacy and safety of C-SEMSs in the management of MPDS.Methods A multiple database search was performed, including MEDLINE, Embase and Cochrane Library, from January 2000 to September 2020, to identify studies reporting the efficacy and safety of C-SEMSs in patients with MPDS. Stricture and pain resolution were investigated. Other outcomes included technical success, stent migration, stricture recurrence and need for repeated stent placement. Pancreatitis, severe abdominal pain requiring stent removal and de-novo stricture were recorded as complications.Results Nineteen studies were identified, which included a total of 300 patients. C-SEMSs showed a pooled stricture resolution rate of 91 % [95 % confidence interval (CI), 85 %-96 %] and a pooled pain resolution rate of 92 % (95 % CI, 85 %-98 %). The pooled proportion for stricture recurrence was equal to 6 % (95 % CI, 1 %-14 %), while stent migration occurred in 33 of 300 patients, the pooled proportion being 7 % (95 % CI 1 %-15 %). The pooled mean stent duration was 133 days (95 % CI, 100-166 days). The most common complication was pancreatitis (3 %, 95 % CI 0 %-8 %), while de-novo stricture pooled proportion was 2 % (95 % CI, 0 %-5 %).Conclusions C-SEMSs are effective and safe in the treatment of MPDS. However, there is a significant need for further high-quality, well-designed studies to produce evidence-based data on short and long-term efficacy, safety, costs of C-SEMSs, and also optimal stent duration

Effect of Combination Folic Acid, Vitamin B6 , and Vitamin B12 Supplementation on Fracture Risk in Women: A Randomized, Controlled Trial.

Epidemiologic studies have demonstrated an association of elevated plasma homocysteine levels with greater bone resorption and fracture risk. Vitamins B12 , B6 , and folic acid are cofactors in homocysteine metabolism, and supplementation with B vitamins is effective in lowering homocysteine levels in humans. However, randomized trials of supplemental B vitamins for reduction of fracture risk have been limited. Therefore, we performed an ancillary study to the Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS), a large randomized trial of women with preexisting cardiovascular disease or three or more coronary risk factors, to test whether a daily B vitamin intervention including folic acid (2.5 mg/day), vitamin B6 (50 mg/day), and vitamin B12 (1 mg/day) reduces nonspine fracture risk over 7.3 years of treatment and follow-up. Among 4810 women, we confirmed 349 nonspine fracture cases by centralized review of medical records. In a substudy of 300 women (150 in treatment group and 150 controls) with paired plasma samples at randomization and follow-up (7.3 years later), we measured two bone turnover markers, including C-terminal cross-linking telopeptide of type I collagen (CTX) and intact type I procollagen N-propeptide (P1NP). In Cox proportional hazards models based on intention-to-treat, we found no significant effects of B vitamin supplementation on nonspine fracture risk (relative hazard = 1.08; 95% confidence interval, 0.88 to 1.34). In a nested case-cohort analysis, there were no significant effects of B vitamins on fracture risk among women with elevated plasma homocysteine levels, or low levels of vitamins B12 or B6 , or folate at baseline. Furthermore, treatment with B vitamins had no effect on change in markers of bone turnover. We found no evidence that daily supplementation with B vitamins reduces fracture risk or rates of bone metabolism in middle-aged and older women at high risk of cardiovascular disease. © 2017 American Society for Bone and Mineral Research

Role of the hydrophobic domain in targeting caveolin-1 to lipid droplets

Although caveolins normally reside in caveolae, they can accumulate on the surface of cytoplasmic lipid droplets (LDs). Here, we first provided support for our model that overaccumulation of caveolins in the endoplasmic reticulum (ER) diverts the proteins to nascent LDs budding from the ER. Next, we found that a mutant H-Ras, present on the cytoplasmic surface of the ER but lacking a hydrophobic peptide domain, did not accumulate on LDs. We used the fact that wild-type caveolin-1 accumulates in LDs after brefeldin A treatment or when linked to an ER retrieval motif to search for mutants defective in LD targeting. The hydrophobic domain, but no specific sequence therein, was required for LD targeting of caveolin-1. Certain Leu insertions blocked LD targeting, independently of hydrophobic domain length, but dependent on their position in the domain. We propose that proper packing of putative hydrophobic helices may be required for LD targeting of caveolin-1

Efektivitas Pendampingan dalam Produksi dan Pengunaan Insektisida Organik di Kelompok Tani Sumber Urip Malang

Indonesia has the potential huge vegetable in the production of organic insecticide. In many areas still needed assistance to the farmer groups to produce and use organic insecticide. The objective of this study was to determine the effectiveness of assistance in the production and use of organic insecticides in Farmers Group Sumber Urip Malang. The design study is cross sectional. Assistance performed 10 times in the production and use of organic insecticides involving 10 Farmers Group Sumber Urip I and 10 Farmers Group Sumber Urip II. Before the assistance do is the pretest and after the assistance do is posttest to knowing the knowledge and skills in the production and use of organic insecticides. Data collection method used was a questionnaire, observation, and interviews, while the method of data analysis used is the paired t-test. The results showed that; 1) there is a significant difference of knowledge production of organic insecticide before and after assistance (t-hit> t-tab0,01, 7.259 > 2.861), 2) there are significant differences of organic insecticide production skills before and after assistance (t-hit > t-tab0,01, 10.057 > 2.861), 3) there are significant differences knowledge of the use of organic insecticides before and after assistance (t-hit > t-tab0,01, 8.731 > 2.861), and 4) there are differences significant organic insecticide USAge skills before and after assistance (t-hit > t-tab0,01, 8.028 > 2.861). From the results of such research can be summed up the results of research that effective assistance to increase skills and knowledge production and use of organic insecticides

Nitrogen sources and net growth efficiency of zooplankton in three Amazon River plume food webs

The plasticity of nitrogen specific net growth efficiency (NGE) in marine mesozooplankton is currently unresolved, with discordant lines of evidence suggesting that NGE is constant, or that it varies with nitrogen source, food availability, and food quality in marine ecosystems. Specifically, the fate of nitrogen from nitrogen fixation is poorly known. We use 15N : 14N ratios in plankton in combination with hydrological data, nutrient profiles, and nitrogen fixation rate measurements to investigate the relationship between new nitrogen sources and the nitrogen specific NGE in three plankton communities along the outer Amazon River plume. The NGE of small (200–500 μm) mesozooplankton was estimated from the δ 15N differences between particulate nitrogen and zooplankton using an open system Rayleigh fractionation model. The transfer efficiency of nitrogen among larger (\u3e 500 μm) mesozooplankton was estimated from the change in δ 15N as a function of zooplankton size. The Amazon River was not a significant source of bioavailable nitrogen anywhere in our study region, and subsurface nitrate was the primary new nitrogen source for the outer shelf community, which was dominated by diatoms. N2 fixation was the principal new nitrogen source at sites of high diatom diazotroph association abundance and at oceanic sites dominated by Trichodesmium spp. and Synechococcus spp. Although we found clear spatial differences in food quantity, food quality, and diazotroph inputs into mesozooplankton, our data show no significant differences in mesozooplankton nitrogen transfer efficiency and NGE (for latter, mean ± SD: 59 ± 10%) among sites

Mapping the dynamical regimes of a SESAM mode-locked VECSEL with long cavity using time series analysis

The different dynamical regions of an optically-pumped SESAM mode-locked, long-cavity VECSEL system with a fundamental pulse repetition frequency of ~200 MHz are investigated. The output power, captured as 250 μs long time series using a sampling rate of 200 GSa/s, for each operating condition of the system, is analyzed to determine the dynamical state. A wavelength range of 985-995 nm and optical pump powers of 10 W-16.3 W is studied. The system produces high quality fundamental passive mode-locking (FML) over an extensive part of the parameter space, but the different dynamical regions outside of FML are the primary focus of this study. We report five types of output: CW emission, FML, modelocking of a few modes, double pulsing, and, semi-stable 4th harmonic mode-locking. The high sampling rate of the oscilloscope, combined with the long duration of the time series analyzed, enables insight into how the structure and substructure of pulses vary systematically over thousands of round trips of the laser cavity. Higher average output power is obtained in regions characterized by semi-stable 4th harmonic mode-locking than observed for FML, raising whether such average powers might be achieved for FML. The observed dynamical transitions from fundamental mode-locking provide insights into instability challenges in developing a stable, widely tunable, low repetition rate, turn-key system; and to inform future modelling of the system

Hectospec, the MMT's 300 Optical Fiber-Fed Spectrograph

The Hectospec is a 300 optical fiber fed spectrograph commissioned at the MMT in the spring of 2004. A pair of high-speed six-axis robots move the 300 fiber buttons between observing configurations within ~300 s and to an accuracy ~25 microns. The optical fibers run for 26 m between the MMT's focal surface and the bench spectrograph operating at R~1000-2000. Another high dispersion bench spectrograph offering R~5,000, Hectochelle, is also available. The system throughput, including all losses in the telescope optics, fibers, and spectrograph peaks at ~10% at the grating blaze in 1" FWHM seeing. Correcting for aperture losses at the 1.5" diameter fiber entrance aperture, the system throughput peaks at $\sim$17%. Hectospec has proven to be a workhorse instrument at the MMT. Hectospec and Hectochelle together were scheduled for 1/3 of the available nights since its commissioning. Hectospec has returned \~60,000 reduced spectra for 16 scientific programs during its first year of operation.Comment: 68 pages, 28 figures, to appear in December 2005 PAS